Mariarosaria Miloso

Date of Birth: August 24th, 1960

Citizenship: Italian

EDUCATION

• PhD in ”Biology and Molecular Pathology”, School of Medicine, University of Napoli Federico II.
• Graduated in Biological Science, Faculty of Science MM. FF. NN. University of Napoli

PROFESSIONAL EXPERIENCE

• Associate Professor of Anatomy c/o School of Medicine and Surgery, Un. Milan-Bicocca (2022-   )
• Assistant Professor of Anatomy c/o School of Medicine and Surgery, Un. Milan-Bicocca (2004-2022)
• Technician (D1 level) c/o Department of Neurosciences and Biomedical Technologies, University of Milano-Bicocca (2001-2003)
• Technician (VII level) c/o Institute of Human Anatomy, School of Medicine, University of Milan (1996-2001).
• Research fellowship c/o Laboratory of Molecular Oncology DIBIT-HSR (San Raffaele Hospital, Milano) (1993-1995).
• PhD fellowship c/o Department of  Biology and Molecular and Cellular Pathology “, School of Medicine, University of Napoli Federico II (1989-1993).

ACADEMIC ACHIEVEMENT

• National Scientific Qualification as ASSOCIATE PROFESSOR, SECTOR 05 / H1 HUMAN ANATOMY, Call 2016 D.D. 1532/2016 (BIOS-12/A)RESEARCH INTERESTS
• Study of the anticancer properties of Hibiscus sabdariffa extract and its products
• Study of the anticancer properties of Rigosertib
• Study on urea derivatives as antineoplastic agents
• Evaluation of Sigma receptor modulators as anticancer agents
• Evaluation of new sodium channel blocker as anticancer agents
• Study of the biological properties and differentiation of mesenchymal stem cells from different sources (bone marrow, adipose tissue, periodontal ligament, dental pulp)
• Evaluation of new sodium channel blocker as anticancer agents
• Evaluation of mechanisms and molecular pathways involved in drug-induced peripheral neuropathy
• Study of the Mitogen Activated Protein Kinases (MAPKs) pathway
• Study of the molecular mechanisms involved in the nervous differentiation induced by retinoic acid

TEACHING ACTIVITIES (BIOS-12/A)

• Human Anatomy for Medical degree in Medicine and Surgery and for Bachelor degree in Biomedical Laboratory Techniques, Dental Hygiene, Physiotherapy ,Neuro and Psychomotor Therapy of the Evolutionary Age, Nursing and Midwifery
• Supervisor for numerous bachelor, degree and PhD thesis

PATENT

• European patent (included Spain, Swiss and  Great Britain), and Internazional patent (USA e Canada) as a Referent Inventor for Università di Milano-Bicocca and  Università di Pavia. Patent title: SUBSTITUTED VINYL PIPERAZINE-PIPERIDINE UREA DERIVATIVES AS ANTICANCER AGEN

GRANTS

• PRIN (2007)
• Futuro in ricerca (2008)
• Fondo di Ateneo Quota Competitiva (FAQC 2017)
• PRIN 2022 (A Sustainable Approach for the Discovery of MultitaRgEt Agents against GlioblastoMa. SUS-DREAM

ACADEMIC POSITIONS

• Member of the School of Medicine and Surgery, University of Milan-Bicocca
• Member of Experimental Neurology Unit (ENU), School of Medicine and Surgery, University of Milan- Bicocca

MEMBERSHIPS

• Italian Society of Human Anatomy and Histology
• Experimental Neurology Unit – School of Medicine and Surgery – University of Milan-Bicocca
• Milan Center for Neuroscience NeuroMi – University of Milan-Bicocca

COLLABORATIONS

• University of Pavia (Drug Science Department)
• CREA Research Unit for Floriculture and Ornamental Species, Sanremo
• University of Parma (Food and Drug Department)
• Department of Experimental and Clinical Medicine, Magna Graecia University of Catanzaro

PEER REVIEW ACTIVITIES

• Reviewer of more than 35 international journals

REVIEWER for NATIONAL AND INTERNATIONAL SCIENTIFIC AGENCIES

• PRIN
• REPRISE (MIUR)
• University of Verona (Bando Ateneo per Ricerca di base)
• University of Cagliari (Fondazione Cariplo – Fondazione di Sardegna)
• National Science Centre (NCN, Poland)
• E-Book (Bentham Science Publisher)

EDITORIAL BOARD

• Molecules
• Frontiers
• World Journal of Stem Cells
• World Journal of Biological Chemistry

SPECIAL ISSUES AND COLLECTION

• Special Issue in Molecules: Recent Advances in Anticancer Drugs
• Special Issue in Molecules: Recent Advances in Anticancer Drugs II
• Special Issue in Molecules: Recent Advances in Anticancer Drugs III

SELECTED PUBLICATIONS

She authored 53 publications on peer-review international journals. Her current H-index is 27

Years 2024- 2019 publications are reported here:

• Cavalloro V, Marchesi N, Linciano P, Rossi D, Campagnoli I, Fossati A, Ahmed KM, Malacrida A, Miloso M, et al. Collina S. (2024) Neurogeneration: can metabolites from Eremurus persicus help. Front  Pharmacol 15:130976
• Malacrida A, Deschamps-Wright M, Rigolio R, Cavaletti G, Miloso M. (2023) Another Brick to Confirm the Efficacy of Rigosertib as Anticancer Agent Int J Mol Sci 24:1721
• Malacrida A, Erriquez J, Hashemi M, Rodriguez-Menendez V, Cassetti A, Cavaletti G, Miloso M. (2022) Evaluation of antitumoral effect of Hibiscus sabdariffa extract on human breast cancer cells. Biochem Biophys Rep.32:101353
• Listro R, Malacrida A, Ambrosio FA, Rossino G, Di Giacomo M, Cavalloro V, Garbagnoli M, Linciano P,Rossi D, Cavaletti G, Costa G, Alcaro S, Miloso M, Collina S. (2022) From Nature to Synthetic Compounds: Novel 1(N),2,3 Trisubstituted-5-oxopyrrolidines Targeting Multiple Myeloma Cells. Int J Mol Sci. 23:1306
• Malacrida A, Cavaletti G, Miloso M. (2021) Rigosertib and Cholangiocarcinoma: A Cell Cycle Affair. Int J Mol Sci. 23:213.
• Malacrida A, Cavalloro V, Martino E, Costa G, Ambrosio FA, Alcaro S, Rigolio R, Cassetti A, Miloso M, Collina S. (2021). Anti-Multiple Myeloma Potential of Secondary Metabolites from Hibiscus sabdariffa-Part 2. Molecules. 26:6596.
• Malacrida A, Rigolio R, Celio L, Damian S, Cavaletti G, Mazzaferro V, Miloso M. (2021) In Vitro Evaluation of Rigosertib Antitumoral and Radiosensitizing Effects against Human Cholangiocarcinoma Cells. Int J Mol Sci. 22:8230.
• Listro R, Stotani S, Rossino G, Rui M, Malacrida A, Cavaletti G, Cortesi M, Arienti C, Tesei A, Rossi D, Giacomo MD, Miloso M, Collina S (2020) Exploring the RC-106 Chemical Space: Design and Synthesis of Novel ( E)-1-(3-Arylbut-2-en-1-yl)-4-(Substituted) Piperazine Derivatives as Potential Anticancer Agents. Front Chem. 38:495
• Malacrida A, Rivara M, Di Domizio A, Cislaghi G, Miloso M, Zuliani V, Nicolini G (2020) 3D proteome-wide scale screening and activity evaluation of a new ALKBH5 inhibitor in U87 glioblastoma cell line. Bioorg Med Chem. 28:115300.
• Malacrida A, Cavalloro V, Martino E, Cassetti A, Nicolini G, Rigolio R, Cavaletti G, Mannucci B, Vasile F, Giacomo MD, Collina S, Miloso M. (2019) Anti-Multiple Myeloma Potential of Secondary Metabolites from Hibiscus sabdariffa Molecules. 24:2500.
• Tesei A, Cortesi M, Pignatta S, Arienti C, Dondio GM, Bigogno C, Malacrida A, Miloso M, Meregalli C, Chiorazzi A, Carozzi V, Cavaletti G, Rui M, Marra A, Rossi D, Collina S. (2019) Anti-tumor Efficacy Assessment of the Sigma Receptor Pan Modulator RC-106. A Promising Therapeutic Tool for Pancreatic Cancer. Front Pharmacol. 10:490.