The Experimental Neurology Unit (ENU) was implemented in 2007 at the University of Milano-Bicocca (School of Medicine and Surgery) with the specific aim to unify different expertise and equipment in a single research team at the highest preclinical level to investigate the pathogenesis of central and peripheral nervous system diseases and to test their treatment.
The main focus was on chemotherapy-induced peripheral neurotoxicity (CIPN), but it has been subsequently extended to multiple sclerosis, innovative drug delivery methods and restorative medicine using cellular transplants. To ensure an effective translational potential toward early clinical application of the results, Prof. Guido Cavaletti, already an internationally-recognized expert with a fairly unique preclinical and clinical commitment in the field of neuroscience, was appointed as head of the ENU since its foundation.
Research topics
Chemotherapy-induced peripheral neurotoxicity (CIPN)
Preclinical research Researchers working at the ENU have originally developed most of the available animal…
Multiple sclerosis
At the ENU innovative treatments for multiple sclerosis are tested in the EAE model, in…
Innovative drug delivery
The use of different types of nanoparticles is tested for their toxicity and effectiveness in…
Restorative medicine
Mesenchymal stem cells are tested for their capacity to modulate the immune response in EAE…
Glioblastoma
Researchers working at the ENU group are involved in several projects concerning glioblastoma. Projects are…
Natural compounds as anticancer therapies
Cancer currently represents one of the main causes of death worldwide. Conventional treatments include surgery,…