Preclinical research Researchers working at the ENU have originally developed most of the available animal models of CIPN using different drugs (cisplatin, carboplatin, oxaliplatin, paclitaxel, docetaxel, bortezomib, epothilones, etc). Also effective in vitro screening models are available. Adult and embryonic
Exploring the effect of novel TLR4 antagonists in chemotherapy-induced peripheral neurotoxicity
Project details ENU Team Leader: Olga Tarasiuk Other ENU members involved: Eleonora Pozzi Coordinator: Mohammed Shaik Funded by: University of Milan Bicocca Total Contribution: 40.000 € Project Duration in months: 12 Start Date: 02.01.2024 End Date: 31.12.2024 Abstract Chemotherapy-induced peripheral
Interplay between NEuroactiVe stEroids and endoplasmic Reticulum-MitOchondRia intEraction: a novel therapeutic horizon in chemotherapy-induced peripheral neurotoxicity (NEVERMORE)
Project details ENU Team Leader: Dr. Cristina Meregalli (PI PROJECT)Other ENU members involved: Dr. Alessio Malacrida, Dr. Elisa TonelliCoordinator: Dr. Cristina MeregalliOther Participants: University of Milan, Università degli Studi del PIEMONTE ORIENTALE “Amedeo Avogadro”-VercelliTotal Contribution: 127.150 €Project Duration in months:
Histone deacetylase 6 (HDAC6) inhibitors: possible neuroprotectors for chemotherapy-induced peripheral neuropathy
Project details ENU Team Leader: GABRIELLA NICOLINIOther ENU members involved: ALESSIO MALACRIDA, MARIAROSARIA MILOSO, LAURA MOLTENI, OLGA TARASIUKCoordinator: GABRIELLA NICOLINIFunded by: FONDAZIONE ISTITUTO FARMACOLOGICO FILIPPO SERPERO ETSTotal Contribution: 85.000 €Project Duration in months: 24Start Date: July 6, 2023End Date: July
Chemotherapy Induced Peripheral Neurotoxicity (CIPN): Why should we care?
Project details ENU Team Leader: Paola Alberti, MD, PhD Other Participants: Elena Lucchese, PhD (Department of Economics, UNIMIB), co-PI Postdoctoral researcher: Monica Perez Gilia, PhD Temporary staff: Laura Montelisciani (data analyst) David Simmer (proof-reader) Ferraro Matteo (data analyst) Letta Gabriele
Understanding the role of tubulin post-translational modification and mitochondrial impairment in bortezomib-induced peripheral neurotoxicity
Project details ENU Team Leader: Dr Cristina Meregalli (PI PROJECT) Other ENU members involved: Dr. Alessio Malacrida, Dr. Gabriella Nicolini, Dr. Olga Tarasiuk and in vivo group Coordinator: Dr Cristina Meregalli Other Participants: Universiity of Columbia, University of Michigan, Università