Alessio Malacrida

Alessio Malacrida graduated in Medical Biotechnology in 2013 and in 2017 he got the PhD in Neuroscience at the University of Milan Bicocca. Since 2018, he is a Post-doctoral fellow at the School of Medicine and Surgery of the University of Milan Bicocca.

He is author of 3 scientific papers on International peer-reviewed journals.

RESEARCH INTEREST

• In vitro antitumoral effects of natural and synthetic compounds.

• Isolation and characterization of active molecules from natural extracts.

• In vitro studies of molecular mechanisms involved in Chemotherapy induced Peripheral Neuropathy.

• Sodium channel inhibitors in cancer cell migration and invasion.

COLLABORATIONS

• “Dipartimento di Scienze del Farmaco” of the University of Pavia.

• “Dipartimento di Scienze degli Alimenti e del Farmaco” of the University of Parma.

• “Unità di ricerca per la floricoltura e specie ornamentali” of Sanremo.

PUBLICATIONS

• Malacrida A, Cavalloro V, Martino E, Cassetti A, Nicolini G, Rigolio R, Cavaletti G, Mannucci B, Vasile F, Giacomo MD, Collina S, Miloso M. Anti-Multiple Myeloma Potential of Secondary Metabolites from Hibiscus sabdariffa.  Molecules. 2019 Jul 9;24(13). pii: E2500.

• Tesei A, Cortesi M, Pignatta S, Arienti C, Dondio GM, Bigogno C, Malacrida A, Miloso M, Meregalli C, Chiorazzi A, Carozzi V, Cavaletti G, Rui M, Marra A, Rossi D, Collina S. Anti-tumor Efficacy Assessment of the Sigma Receptor Pan Modulator RC-106. A Promising Therapeutic Tool for Pancreatic Cancer. Front Pharmacol. 2019 May 14;10:490.

• Malacrida A, Meregalli C, Rodriguez-Menendez V, Nicolini G. Chemotherapy-Induced Peripheral Neuropathy and Changes in Cytoskeleton. Int J Mol Sci. 2019 May 9;20(9). pii: E2287.

• Rui M, Rossino G, Coniglio S, Monteleone S, Scuteri A., Malacrida A, Rossi D, Catenacci L, Sorrenti M, Paolillo M, Curti D, Venturini L, Schepmann D, Wünsch B,Liedl KR, Cavaletti G, Pace V, Urban E, Collina S. Identification of dual Sigma1 receptor modulators/acetylcholinesterase inhibitors with antioxidant and neurotrophic properties, as neuroprotective agents. Eur J Med Chem. 2018 Oct 5;158:353-370. doi: 10.1016/j.ejmech.2018.09.010.

• Collina S, Rui M, Stotani S, Bignardi E, Rossi D, Curti D, Giordanetto F, Malacrida A, Scuteri A, Cavaletti G. Are sigma receptor modulators a weapon against multiple sclerosis disease? Future Med Chem. 2017 Nov;9(17):2029-2051. doi: 10.4155/fmc-2017-0122. Epub 2017 Oct 27.

• Malacrida A, Maggioni D, Cassetti A, Nicolini G, Cavaletti G, Miloso M. Antitumoral Effect of Hibiscus sabdariffa on Human Squamous Cell Carcinoma and Multiple Myeloma Cells. Nutr Cancer. 2016 Oct;68(7):1161-70. doi: 10.1080/01635581.2016.1208830. Epub 2016 Aug 11.

• Marra A, Rossi D, Pignataro L, Bigogno C, Canta A, Oggioni N, Malacrida A, Corbo M, Cavaletti G, Peviani M, Curti D, Dondio G, Collina S. Toward the identification of neuroprotective agents: g-scale synthesis, pharmacokinetic evaluation and CNS distribution of (R)-RC-33, a promising SIGMA1 receptor agonist. Future Med Chem. 2016;8(3):287-95. doi: 10.4155/fmc.15.191. Epub 2016 Feb 22.

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