Federico Iseppon

Federico Iseppon graduated in Neurobiology (MSc) from the University of Pavia in 2012 and holds a Ph.D. in Neurobiology from SISSA – International School of Advanced Studies (2016).

From 2017 to 2024 he worked as a Research Associate in the Molecular Nociception Laboratory at the University College London, managing numerous projects about the molecular bases of pain and sensation, the mechanisms of action of analgesic drugs for pain treatment in Chemotherapy-Induced Peripheral Neuropathies (CIPN) in collaboration with AstraZeneca, and the development of novel gene and cellular therapy approaches for the treatment of pain.

He is currently working within the Experimental Neurology Unit in the University of Milano-Bicocca on different research projects investigating the molecular mechanisms of peripheral neurotoxicity of proteasome inhibitor drugs.

 

RESEARCH INTERESTS

• Investigation and analysis of physiological and pathological neuronal activity, as well as drug efficacy, using in vitro and in vivo imaging approaches

• Preclinical evaluation of pain (acute, inflammatory, neuropathic) and CIPN

• Preclinical evaluation of neurotoxicity mechanisms and novel therapeutic strategies for CIPN

• Discovery of novel therapeutic approaches for pain treatment

 

MOST RELEVANT PUBLICATIONS

• Iseppon, F.*, Malacrida, A.*, Chiorazzi, A., Canta, A., Alberti, P., Carozzi, V. A., Pozzi, E., Rodriguez-Menendez, V., Cherchi, L., Fabbro, V., Pagani, L., Tonelli, E., Tapella, L., Mattarei, A., Palermo, S., Cartelli, D., Mauri, M., Scimia, N., Stanga, S., … Meregalli, C. (2026). Shared and specific molecular mechanisms of proteasome inhibitors in chemotherapy-induced peripheral neurotoxicity. British Journal of Pharmacology, 1–28. https://doi.org/10.1111/bph.70501 (* these authors contributed equally)

• Iseppon F, Kanellopoulos AH, Tian N, Zhou J, Caan G, Chiozzi R, Thalassinos K, Çubuk C, Lewis MJ, Cox JJ, Zhao J, Woods CG, Wood JN. Sodium channels Na_v7, Na_v1.8 and pain; two distinct mechanisms for Na_v1.7 null analgesia. Neurobiol Pain. 2024 Oct 11;16:100168. doi: 10.1016/j.ynpai.2024.100168. PMID: 39559752; PMCID: PMC11570969.

• M Ali Bangash*, Cankut Cubuk*, Federico Iseppon*, Rayan Haroun, Chloe Garcia, Ana P Luiz, Manuel Arcangeletti, Samuel J Gossage, Sonia Santana-Varela, James J Cox, Myles J Lewis, John N Wood, Jing Zhao Analgesic targets identified in mouse sensory neuron somata and terminal pain translatomes Cell Reports, Volume 43, Issue 8, 114614 https://doi.org/1016/j.celrep.2024.114614. (* these authors contributed equally)

• Iseppon F, Luiz AP, Linley JE, Wood JN. Pregabalin Silences Oxaliplatin-Activated Sensory Neurons to Relieve Cold Allodynia. eNeuro. 2023 Feb 21;10(2):ENEURO.0395-22.2022. doi: 10.1523/ENEURO.0395-22.2022.

• Iseppon F, Linley JE, Wood JN. Calcium imaging for analgesic drug discovery. Neurobiology of Pain, Volume 11, 2022, doi: 10.1016/j.ynpai.2021.100083

• MacDonald DI, Luiz AP, Iseppon F, Millet Q, Emery EC, Wood JN. Silent cold-sensing neurons contribute to cold allodynia in neuropathic pain. Brain. 2021 Jul 28;144(6):1711-1726. doi: 10.1093/brain/awab086.

• Mortal S*, Iseppon F*, Napolitano LMR, Perissinotto A, D’Este E, Cojoc D, Torre V. Function and mechanism of Actin Waves Frontiers in Cellular Neuroscience, 2017 Dec 18;11:402. doi: 10.3389/fncel.2017.00402 (* these authors contributed equally).

• Iseppon F, Napolitano LMR, Torre V, Cojoc D. Combining FRET and optical tweezers to study Rho-GTPases spatio-temporal dynamics upon local stimulation. J Biol Methods 2017;4(1):e65. doi: 10.14440/jbm.2017.159