Author: enu@unimib.it

Interplay between NEuroactiVe stEroids and endoplasmic Reticulum-MitOchondRia intEraction: a novel therapeutic horizon in chemotherapy-induced peripheral neurotoxicity (NEVERMORE)

Project details ENU Team Leader: Dr. Cristina Meregalli (PI PROJECT)Other ENU members involved: Dr. Alessio Malacrida, Dr. Elisa TonelliCoordinator: Dr. Cristina MeregalliOther Participants: University of Milan, Università degli Studi del PIEMONTE ORIENTALE “Amedeo Avogadro”-VercelliTotal Contribution: 127.150 €Project Duration in months:

The vascular contribution in chemotherapy-induced painful peripheral neuropathy: beyond the neurocentric view and towards novel therapeutic targets

Project details ENU Team Leader: VALENTINA ALDA CAROZZI Other ENU members involved: ARIANNA SCUTERI, ELEONORA POZZI Coordinator: VALENTINA ALDA CAROZZI, ELEONORA POZZI Other Participants: ANTONIO ZIPPO (CNR), DANIELE RAMAZZOTTI (University of Milano-Bicocca) Total Contribution: 259184 €Project Duration in months: 24Start

Histone deacetylase 6 (HDAC6) inhibitors: possible neuroprotectors for chemotherapy-induced peripheral neuropathy

Project details ENU Team Leader: GABRIELLA NICOLINIOther ENU members involved: ALESSIO MALACRIDA, MARIAROSARIA MILOSO, LAURA MOLTENI, OLGA TARASIUKCoordinator: GABRIELLA NICOLINIFunded by: FONDAZIONE ISTITUTO FARMACOLOGICO FILIPPO SERPERO ETSTotal Contribution: 85.000 €Project Duration in months: 24Start Date: July 6, 2023End Date: July

Sodium-calcium exchanger (NCX) and ion channels: pivotal elements leading to axonal damage in peripheral nerves? (IonNerve project)

Project details ENU Team Leader: Paola Alberti, MD, PhDOther ENU members involved: Temporary staff hired on Cariplo grant: Margherita Kraus, DVM; Chiara Invernizzi, MSc; Sara Di Girolamo, PhD ENU staff assisting the IonNerve team: Gabriella Nicolini, PhD; Elisa Ballarini, PhD;

Multidisciplinary approach to optimize the promising anti glioblastoma candidate MV1035

Project details ENU Team Leader: GABRIELLA NICOLINI Other ENU members involved: ALESSIO MALACRIDA Coordinator: GABRIELLA NICOLINI Other Participants: FRANCESCA RE (School of Medicine and Surgery, University of Milano-Bicocca), MIRKO RIVARA (Food and Drug Department, University of Parma), VALENTINA ZULIANI (Food

ANTHEM – AdvaNced Technology for Human centEred Medicine

Project details ENU Team Leader: Guido Cavaletti Over 250 Participants from 23 Institutions are invoived. Total Contribution: 123.477.500,47 €Project Duration: 48 monthsStart Date: December 2022End Date: December 2026Project webpage: www.fondazioneanthem.it Abstract ANTHEM – AdvaNced Technologies for Human-centred Medicine is an

Chemotherapy Induced Peripheral Neurotoxicity (CIPN): Why should we care?

Project details ENU Team Leader: Paola Alberti, MD, PhD Other Participants: Elena Lucchese, PhD (Department of Economics, UNIMIB), co-PI Postdoctoral researcher: Monica Perez Gilia, PhD Temporary staff: Laura Montelisciani (data analyst) David Simmer (proof-reader) Ferraro Matteo (data analyst) Letta Gabriele

Understanding the role of tubulin post-translational modification and mitochondrial impairment in bortezomib-induced peripheral neurotoxicity

Project details ENU Team Leader: Dr Cristina Meregalli (PI PROJECT) Other ENU members involved: Dr. Alessio Malacrida, Dr. Gabriella Nicolini, Dr. Olga Tarasiuk and in vivo group Coordinator: Dr Cristina Meregalli Other Participants: Universiity of Columbia, University of Michigan, Università