Roberta Rigolio

Technical expert

+30 02 6448 8114
Roberta Rigolio


Dr Rigolio, MSc in Medical Biotechnologies and PhD in Neuroscience, worked in-vitro, in vivo and ex-vivo on CNS neuroimmunology related disorders, i.e. Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis (EAE).

Principal investigator of founded projects on neutrophil contribution in EAE development and on innate immunity molecular biomarkers in MS, she supported ENU research on neuroinflammation in peripheral nervous system and other on-going in-vitro and ex-vivo research topics not only through her flow cytometric know how.

At the present, she is supporting ENU research projects while acting as Science and Technological Platform Manager of U28, “the house of the Research”, an interdepartmental research building placed in the UNIMIB Biomedical of Monza.


  • Experimental Autoimmune Encephalomyelitis: pathogenesis, disease biomarkers and biophysical approaches in studying disease course
  • Multiple Sclerosis: Innate immunity and molecular biomarkers. 
  • Strategies in limiting cancer cell development and proliferation (mainly nanoparticles and natural compounds)


  1. Malacrida A, Rigolio R, Celio L, Damian S, Cavaletti G, Mazzaferro , Miloso M. In Vitro Evaluation of Rigosertib Antitumoral and Radiosensitizing Effects against Human Cholangiocarcinoma Cells. Int. J. Mol. Sci. 2021,22(15), 8230; 
  2. Malacrida A., Cavalloro V., Martino E., Costa G., Ambrosio F.A., Alcaro S., Rigolio R., Cassetti A., Miloso M, Collina S. Anti-Multiple Myeloma Potential of Secondary Metabolites from Hibiscus sabdariffa—Part 2. Molecules 2021, 26, 6596 molecules26216596
  3. Fumagalli G, Monza L, Cavaletti G, Rigolio R*, Meregalli C. Neuroinflammatory process involved in different preclinical models of chemotherapy-induced peripheral neuropathy. Frontiers in Immunology. 2021, 11:626687 doi: 10.3389/fimmu.2020.626687.* Corresponding Author
  4. Giatti S, Rigolio R, Diviccaro S, Falvo E, Caruso D, Garcia-Segura L, Cavaletti G, Melcangi RC. Sex dimorphism in an animal model of multiple sclerosis: focus on pregnenolone synthesis. Journal of Steroid Biochemistry and Molecular Biology. 2020, 199:105596. doi: 10.1016/j.jsbmb.2020.105596. 
  5. Formicola B, D’Aloia A, Dal Magro Ra, Stucchi S, Rigolio R, Ceriani M, Re F. Differential Exchange of Multifunctional Liposomes Between Glioblastoma Cells and Healthy Astrocytes via Tunneling Nanotubes. 2019 Frontiers in Bioengineering and Biotechnology 2019. 7:403 DOI=10.3389/fbioe.2019.00403 
  6. Potenzieri A, Riva B, Rigolio R, Chiorazzi A, Pozzi E, Ballarini E, Cavaletti G, Genazzani AA.Oxaliplatin-induced neuropathy occurs through impairment of haemoglobin proton buffering and is reversed by carbonic anhydrase inhibitors. Pain. 2019 doi: 10.1097/j.pain.0000000000001722
  7. Malacrida A, Cavalloro V, Martino E, Cassetti A, Nicolini G, Rigolio R, Cavaletti G, Mannucci B, Vasile F, Giacomo MD, Collina S, Miloso M. Anti-Multiple Myeloma Potential of Secondary Metabolites from Hibiscus sabdariffa.Molecules. 2019 Jul 9;24(13). pii: E2500. doi: 10.3390/molecules24132500.
  8. Multimodal analysis in acute and chronic experimental autoimmune encephalomyelitis. Giatti S, Boraso M, Abbiati F, Ballarini E, Calabrese D, Santos-Galindo M, Rigolio R, Pesaresi M, Caruso D, Viviani B, Cavaletti G, Garcia-Segura LM, Melcangi RC. J Neuroimmune Pharmacol. 2013;8(1):238-50 
  9. Neuroprotective effects of progesterone in chronic experimental autoimmune encephalomyelitis. Giatti S, Caruso D, Boraso M, Abbiati F, Ballarini E, Calabrese D, Pesaresi M, Rigolio R, Santos-Galindo M, Viviani B, Cavaletti G, Garcia-Segura LM, Melcangi RC. J Neuroendocrinol. 2012;24(6):851-61. 
  10. Actively induced EAE in Lewis rats: characterization of spleen and spinal cord infiltrating lymphocytes by flow cytometry during the course of the disease. Rigolio R, Biffi A, Oggioni N, Cavaletti G. J Neuroimmunol. 2008, 13;199(1-2):67-74. 
  11. Apigenin impairs oral squamous cell carcinoma growth in vitro inducing cell cycle arrest and apoptosis. Maggioni D, Garavello W, Rigolio R, Pignataro L, Gaini R, Nicolini G. Int J Oncol. 2013;43(5):1675-82. 
  12. Functionalized mesoporous silica nanoparticles: a possible strategy to target cancer cells reducing peripheral nervous system uptake. Ceresa C, Nicolini G, Rigolio R, Bossi M, Pasqua L, Cavaletti G. Curr Med Chem. 2013;20(20):2589-600.


  • Università del Piemonte Occidentale: Dr. B. Riva
  • Università degli Studi di Milano: Prof. R. Melcangi and Dr S. Giatti 
  • Università Vita e Salute San Raffaele (Dr. M. Battaglia and Dr. G. Fousteri)
  • University of Cambridge: Dr. S. Pluchino and Dr. L. Peruzzotti-Jametti
  • Istituto Italiano di Tecnologia (NEST)- Center for Nanotechnology Innovation: Dr. P Parlanti e Dr. V. Cappello, Dr V. Piazza.
  • Università degli Studi di Verona: Dr P. Marzola and Dr. G. Malerba