Curriculum Vitae
Born in 1983, she graduated in Medical Biotechnology in 2007 at the University of Milano-Bicocca and she got the PhD in Neuroscience in 2010 at the University of Milano-Bicocca. Now is a technical expert and she works with Prof.Cavaletti in in vivo research in the field of chemotherapy-induced neurotoxicity.
In this period she investigated the use of antineoplastic drugs and the damages induced by these drugs on the peripheral nervous system. In the laboratory of Prof.Cavaletti she developed her ability in animal studies and now, in the School of Medicine and Surgery of the University of Milano-Bicocca, she exercises a role of collaboration in the conduction of in vivo experiments performed to study the peripheral painful neuropathies induced by chemotherapy drugs.
Since 2008 she has been involved in collaborative studies with National and International Research Institutes such as the “M. Negri Pharmaceutical Research Institute, Milan” and “Sigma Tau, Rome” and in 2012 she visited the laboratory of Prof. Susan Dorsey at the Centre of Pain Study, School of Nursing, University of Maryland, Baltimore (MD). During these collaborations she performed the neurophysiological analysis to study the neuropathy induced by antineoplastic drugs in mice.
In November 2017 she has completed with success the FELASA Accredited Course F 023/09 that covered mice and rats species.
She is author of 48 scientific papers on International peer-reviewed journals and 2 book chapters.
SKILLS
In vivo techniques:
- Intra-peritoneal, intra-venous and oral drug administration
- intra-cardiac perfusion
- organ explants
- blood sampling
- plantar test
- morphological and morphometrical analysis
- neurophysiological study
- tumor cells injection
Processing of specimens for light and electron microscopy using standard methods.
Protein extraction from cell cultures and whole tissues
SDS-PAGE electrophoresis
Western Blot
MOST RELEVANT PUBLICATIONS
- Calmangafodipir Reduces Sensory Alterations and Prevents Intraepidermal Nerve Fibers Loss in a Mouse Model of Oxaliplatin Induced Peripheral Neurotoxicity. Canta A, Chiorazzi A, Pozzi E, Fumagalli G, Monza L, Meregalli C, Carozzi VA, Rodriguez-Menendez V, Oggioni N, Näsström J, Marmiroli P, Cavaletti G. Antioxidants (Basel). 2020. doi: 10.3390/antiox9070594.
- Neurofilament light chain: a specific serum biomarker of axonal damage severity in rat models of Chemotherapy-Induced Peripheral Neurotoxicity. Meregalli C, Fumagalli G, Alberti P, Canta A, Chiorazzi A, Monza L, Pozzi E, Carozzi VA, Blennow K, Zetterberg H, Cavaletti G, Marmiroli P. Arch Toxicol. 2020. doi: 10.1007/s00204-020-02755-w. Epub 2020 Apr 24.
- Neuronal uptake transporters contribute to oxaliplatin neurotoxicity in mice. Huang KM, Leblanc AF, Uddin ME, Kim JY, Chen M, Eisenmann ED, Gibson AA, Li Y, Hong KW, DiGiacomo D, Xia SH, Alberti P, Chiorazzi A, Housley SN, Cope TC, Sprowl JA, Wang J, Loprinzi CL, Noonan A, Lustberg MB, Cavaletti G, Pabla N, Hu S, Sparreboom A. J Clin Invest. 2020. doi: 10.1172/JCI136796.
- Translating morphology from bench side to bed side via neurophysiology: 8-min protocol for peripheral neuropathy research. Monza L, Fumagalli G, Chiorazzi A, Alberti P. J Neurosci Methods. 2021 Nov 1;363:109323. doi: 10.1016/j.jneumeth.2021.109323. Epub 2021 Aug 13.
- Topiramate prevents oxaliplatin-related axonal hyperexcitability and oxaliplatin induced peripheral neurotoxicity. Neuropharmacology. Alberti P, Canta A, Chiorazzi A, Fumagalli G, Meregalli C, Monza L, Pozzi E, Ballarini E, Rodriguez-Menendez V, Oggioni N, Sancini G, Marmiroli P, Cavaletti G. 2020. doi: 10.1016/j.neuropharm.2019.107905. Epub 2019 Dec 4.